“Spinocerebellar ataxias, dominantly inherited ataxias, constitute a large heterogenous group of progressive neurodegenerative disorders that commonly affects the cerebellum and its afferent and efferent pathways. No pharmacological treatment has been found to be effective in the treatment of spinocerebellar ataxias. Stem cellbased therapy is emerging as a promising therapeutic option for the treatment of Spinocerebellar ataxias. In this case report, three patients with spinocerebellar ataxias were treated with human embryonic stem cells. Following the treatment, all patient showed noticeable changes in their health such improvement in hand eye coordination, gait pattern, ability to stand without support, muscle strength in all the limbs, ability to walk and turn while standing without support, clearance in speech, good energy levels, reduction in twitching of cheek muscle, stamina, endurance and coordination. “